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Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington’s Disease

BACKGROUND: Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. We previously discovered that mutant Huntingtin sensitizes type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) to InsP(3). This causes calcium leakag...

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Detalles Bibliográficos
Publicado en:J Huntingtons Dis
Autores principales: Wu, Jun, Ryskamp, Daniel, Birnbaumer, Lutz, Bezprozvanny, Ilya
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309623/
https://ncbi.nlm.nih.gov/pubmed/29480205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170266
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