Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

In Huntington's disease (HD), mutant Huntingtin (mHtt) protein causes striatal neuron dysfunction, synaptic loss, and eventual neurodegeneration. To understand the mechanisms responsible for synaptic loss in HD, we developed a corticostriatal coculture model that features age-dependent dendriti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wu, Jun, Ryskamp, Daniel A., Liang, Xia, Egorova, Polina, Zakharova, Olga, Hung, Gene, Bezprozvanny, Ilya
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701955/
https://ncbi.nlm.nih.gov/pubmed/26740655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1038-15.2016
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados