Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington’s disease treatment

Huntington’s disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion within Huntingtin (Htt) protein. In the phenotypic screen we identified a class of quinazoline-derived compounds which delayed a progression of a motor phenotype in transgenic Drosophila HD flies. We found...

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Hlavní autoři: Wu, Jun, Shih, Hsin-Pei, Vigont, Vladimir, Hrdlicka, Lori, Diggins, Len, Singh, Carol, Mahoney, Matt, Chesworth, Richard, Shapiro, Gideon, Zimina, Olga, Chen, Xuesong, Wu, Qingqing, Glushankova, Lyubov, Ahlijanian, Michael, Koenig, Gerhard, Mozhayeva, Galina N., Kaznacheyeva, Elena, Bezprozvanny, Ilya
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124661/
https://ncbi.nlm.nih.gov/pubmed/21700213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.04.012
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