Circulating protein synthesis rates reveal skeletal muscle proteome dynamics

Here, we have described and validated a strategy for monitoring skeletal muscle protein synthesis rates in rodents and humans over days or weeks from blood samples. We based this approach on label incorporation into proteins that are synthesized specifically in skeletal muscle and escape into the ci...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Shankaran, Mahalakshmi, King, Chelsea L., Angel, Thomas E., Holmes, William E., Li, Kelvin W., Colangelo, Marc, Price, John C., Turner, Scott M., Bell, Christopher, Hamilton, Karyn L., Miller, Benjamin F., Hellerstein, Marc K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2015
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701543/
https://ncbi.nlm.nih.gov/pubmed/26657858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79639
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