The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be b...

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Autori principali: Price, John C., Khambatta, Cyrus F., Li, Kelvin W., Bruss, Matthew D., Shankaran, Mahalakshmi, Dalidd, Marcy, Floreani, Nicholas A., Roberts, Lindsay S., Turner, Scott M., Holmes, William E., Hellerstein, Marc K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2012
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518108/
https://ncbi.nlm.nih.gov/pubmed/22984287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.021204
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