The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be b...

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Detalhes bibliográficos
Main Authors: Price, John C., Khambatta, Cyrus F., Li, Kelvin W., Bruss, Matthew D., Shankaran, Mahalakshmi, Dalidd, Marcy, Floreani, Nicholas A., Roberts, Lindsay S., Turner, Scott M., Holmes, William E., Hellerstein, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518108/
https://ncbi.nlm.nih.gov/pubmed/22984287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.021204
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