The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitness. At steady state, increased catabolism must be b...

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Main Authors: Price, John C., Khambatta, Cyrus F., Li, Kelvin W., Bruss, Matthew D., Shankaran, Mahalakshmi, Dalidd, Marcy, Floreani, Nicholas A., Roberts, Lindsay S., Turner, Scott M., Holmes, William E., Hellerstein, Marc K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518108/
https://ncbi.nlm.nih.gov/pubmed/22984287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.021204
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