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Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice

Combating the social and economic consequences of a growing elderly population will require the identification of interventions that slow the development of age‐related diseases. Preserved cellular homeostasis and delayed aging have been previously linked to reduced cell proliferation and protein sy...

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發表在:Aging Cell
Main Authors: Thompson, Airlia C. S., Bruss, Matthew D., Price, John C., Khambatta, Cyrus F., Holmes, William E., Colangelo, Marc, Dalidd, Marcy, Roberts, Lindsay S., Astle, Clinton M., Harrison, David E., Hellerstein, Marc K.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717272/
https://ncbi.nlm.nih.gov/pubmed/26541492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12414
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