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Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice

Combating the social and economic consequences of a growing elderly population will require the identification of interventions that slow the development of age‐related diseases. Preserved cellular homeostasis and delayed aging have been previously linked to reduced cell proliferation and protein sy...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Thompson, Airlia C. S., Bruss, Matthew D., Price, John C., Khambatta, Cyrus F., Holmes, William E., Colangelo, Marc, Dalidd, Marcy, Roberts, Lindsay S., Astle, Clinton M., Harrison, David E., Hellerstein, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717272/
https://ncbi.nlm.nih.gov/pubmed/26541492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12414
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