Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice

Calorie restriction (CR) delays aging and extends lifespan in numerous organisms, including mice. Down-regulation of the somatotropic axis, including a reduction in insulin-like growth factor-1 (IGF-1), likely plays an important role in CR-induced lifespan extension, possibly by reducing cell prolif...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Thompson, Airlia C. S., Bruss, Matthew D., Nag, Nitish, Kharitonenkov, Alexei, Adams, Andrew C., Hellerstein, Marc K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4219748/
https://ncbi.nlm.nih.gov/pubmed/25369265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111418
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