Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism. Pharmacological doses of FGF21 improve glucose tolerance, lower serum free fatty acids, and lead to weight loss in obese mice. Surprisingly, however, FGF21 levels are elevated in obese ob/o...

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Autori principali: Fisher, ffolliott M., Chui, Patricia C., Antonellis, Patrick J., Bina, Holly A., Kharitonenkov, Alexei, Flier, Jeffrey S., Maratos-Flier, Eleftheria
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963536/
https://ncbi.nlm.nih.gov/pubmed/20682689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0193
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