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Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a key mediator of fatty acid oxidation and lipid metabolism. Pharmacological doses of FGF21 improve glucose tolerance, lower serum free fatty acids, and lead to weight loss in obese mice. Surprisingly, however, FGF21 levels are elevated in obese ob/o...

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主要な著者: Fisher, ffolliott M., Chui, Patricia C., Antonellis, Patrick J., Bina, Holly A., Kharitonenkov, Alexei, Flier, Jeffrey S., Maratos-Flier, Eleftheria
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963536/
https://ncbi.nlm.nih.gov/pubmed/20682689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0193
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