Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

OBJECTIVE: Non-alcoholic fatty liver (NAFL) associated with obesity is a major cause of liver diseases which can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Fibroblast growth factor 21 (FGF21) plays an important role in liver metabolism and is also a pot...

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Pubblicato in:Mol Metab
Autori principali: Singhal, Garima, Kumar, Gaurav, Chan, Suzanne, Fisher, ffolliott M., Ma, Yong, Vardeh, Hilde G., Nasser, Imad A., Flier, Jeffrey S., Maratos-Flier, Eleftheria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026320/
https://ncbi.nlm.nih.gov/pubmed/29753678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.03.002
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