Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases

β-Lactamase inhibitors (BLIs) restore the efficacy of otherwise obsolete β-lactams. However, commercially available BLIs are not effective against metallo-β-lactamases (MBLs), which continue to be disseminated globally. One group of the most clinically important MBLs is the VIM family. The discovery...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Mojica, Maria F., Mahler, S. Graciela, Bethel, Christopher R., Taracila, Magdalena A., Kosmopoulou, Magda, Papp-Wallace, Krisztina M., Llarrull, Leticia I., Wilson, Brigid M., Marshall, Steven H., Wallace, Christopher J., Villegas, Maria V., Harris, Michael E., Vila, Alejandro J., Spencer, James, Bonomo, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700511/
https://ncbi.nlm.nih.gov/pubmed/25915520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00106
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