Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma — Prognostic and Translational Implications()

Renal cell carcinoma (RCC) is characterized by a profound disruption of proapoptotic signaling networks leading to chemo- and radioresistance. A key mediator of DNA damage-induced apoptosis is the BH3-only protein PUMA. Given its central role in proapoptotic signaling, we analyzed a series of more t...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Zhou, Xiaoguang, Li, Jielin, Marx, Christina, Tolstov, Yanis, Rauch, Geraldine, Herpel, Esther, Macher-Goeppinger, Stephan, Roth, Wilfried, Grüllich, Carsten, Pahernik, Sascha, Hohenfellner, Markus, Duensing, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2015
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700292/
https://ncbi.nlm.nih.gov/pubmed/26692529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2015.11.003
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