Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal cell carcinoma (ccRCC). Here we address the question whether ITH increases with malignant progression and can hence be exploited as a prognostic m...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hoefflin, Rouven, Lahrmann, Bernd, Warsow, Gregor, Hübschmann, Daniel, Spath, Cathleen, Walter, Britta, Chen, Xin, Hofer, Luisa, Macher-Goeppinger, Stephan, Tolstov, Yanis, Korzeniewski, Nina, Duensing, Anette, Grüllich, Carsten, Jäger, Dirk, Perner, Sven, Schönberg, Gita, Nyarangi-Dix, Joanne, Isaac, Sanjay, Hatiboglu, Gencay, Teber, Dogu, Hadaschik, Boris, Pahernik, Sascha, Roth, Wilfried, Eils, Roland, Schlesner, Matthias, Sültmann, Holger, Hohenfellner, Markus, Grabe, Niels, Duensing, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910022/
https://ncbi.nlm.nih.gov/pubmed/27291893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11845
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