Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

Intratumoural heterogeneity (ITH) is a major cause of cancer-associated lethality. Extensive genomic ITH has previously been reported in clear cell renal cell carcinoma (ccRCC). Here we address the question whether ITH increases with malignant progression and can hence be exploited as a prognostic m...

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Udgivet i:Nat Commun
Main Authors: Hoefflin, Rouven, Lahrmann, Bernd, Warsow, Gregor, Hübschmann, Daniel, Spath, Cathleen, Walter, Britta, Chen, Xin, Hofer, Luisa, Macher-Goeppinger, Stephan, Tolstov, Yanis, Korzeniewski, Nina, Duensing, Anette, Grüllich, Carsten, Jäger, Dirk, Perner, Sven, Schönberg, Gita, Nyarangi-Dix, Joanne, Isaac, Sanjay, Hatiboglu, Gencay, Teber, Dogu, Hadaschik, Boris, Pahernik, Sascha, Roth, Wilfried, Eils, Roland, Schlesner, Matthias, Sültmann, Holger, Hohenfellner, Markus, Grabe, Niels, Duensing, Stefan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910022/
https://ncbi.nlm.nih.gov/pubmed/27291893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11845
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