The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse

Obese leptin-deficient (ob/ob) mice demonstrate defects in upper airway structural and neuromuscular control. We hypothesized that these defects predispose to upper airway obstruction during sleep, and improve with leptin administration. High-fidelity polysomnographic recordings were conducted to ch...

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Bibliographic Details
Published in:J Appl Physiol (1985)
Main Authors: Pho, H., Hernandez, A. B., Arias, R. S., Leitner, E. B., Van Kooten, S., Kirkness, J. P., Schneider, H., Smith, P. L., Polotsky, V. Y., Schwartz, A. R.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698442/
https://ncbi.nlm.nih.gov/pubmed/26472867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00494.2015
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