Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity

Rationale: Leptin treats upper airway obstruction and alveolar hypoventilation in leptin-deficient ob/ob mice. However, obese humans and mice with diet-induced obesity (DIO) are resistant to leptin because of poor permeability of the blood–brain barrier. We propose that intranasal leptin will bypass...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Berger, Slava, Pho, Huy, Fleury-Curado, Thomaz, Bevans-Fonti, Shannon, Younas, Haris, Shin, Mi-Kyung, Jun, Jonathan C., Anokye-Danso, Frederick, Ahima, Rexford S., Enquist, Lynn W., Mendelowitz, David, Schwartz, Alan R., Polotsky, Vsevolod Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423095/
https://ncbi.nlm.nih.gov/pubmed/30309268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201805-0879OC
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