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Central Leptin Gene Therapy Corrects Skeletal Abnormalities in Leptin-deficient ob/ob Mice
Skeletal growth is tightly coupled to energy balance via complex and incompletely understood mechanisms. Leptin-deficient ob/ob mice are obese and develop multiple pathologies associated with the metabolic syndrome. Additionally, ob/ob mice have skeletal abnormalities. The objective of this study wa...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1986832/ https://ncbi.nlm.nih.gov/pubmed/17346852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2007.02.001 |
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