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Central Leptin Gene Therapy Corrects Skeletal Abnormalities in Leptin-deficient ob/ob Mice
Skeletal growth is tightly coupled to energy balance via complex and incompletely understood mechanisms. Leptin-deficient ob/ob mice are obese and develop multiple pathologies associated with the metabolic syndrome. Additionally, ob/ob mice have skeletal abnormalities. The objective of this study wa...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1986832/ https://ncbi.nlm.nih.gov/pubmed/17346852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2007.02.001 |
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