CONFORMATIONAL SEARCHES ELUCIDATE EFFECTS OF STEREOCHEMISTRY ON STRUCTURES OF DEOXYADENOSINE COVALENTLY BOUND TO TUMORIGENIC METABOLITES OF BENZO[C] PHENANTHRENE

Remarkably different conformations can result when DNA binds with stereoisomeric compounds containing differing absolute configurations of substituents about chiral carbon atoms. Furthermore, the biochemical functions of covalent adducts with DNA are strongly affected by the stereochemistry of the l...

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Veröffentlicht in:Front Biosci
Hauptverfasser: Wu, Min, Yan, S. Frank, Tan, Jian, Patel, Dinshaw J., Geacintov, Nicholas E., Broyde, Suse
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697942/
https://ncbi.nlm.nih.gov/pubmed/15353316
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