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Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling
Discussions of therapeutic suppression of hedgehog (Hh) signaling almost exclusively focus on receptor antagonism; however, hedgehog’s biosynthesis represents a unique and potentially targetable aspect of this oncogenic signaling pathway. Here, we review a key biosynthetic step called cholesterolysi...
Gardado en:
| Publicado en: | Cancers (Basel) |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4695875/ https://ncbi.nlm.nih.gov/pubmed/26473928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers7040875 |
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