LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8(+) T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

The immune co-inhibitory receptors lymphocyte activation gene-3 (LAG3) and programmed cell death 1 (PD1) synergistically contribute to autoimmunity and tumor evasion. Here we demonstrate how they collaborate and interact to regulate T cell function. We first show that LAG3 and PD1 are co-expressed o...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Huang, Ruea-Yea, Eppolito, Cheryl, Lele, Shashikant, Shrikant, Protul, Matsuzaki, Junko, Odunsi, Kunle
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694995/
https://ncbi.nlm.nih.gov/pubmed/26318293
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