Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer

Tumor-associated or -infiltrating lymphocytes (TALs or TILs) co-express multiple immune inhibitory receptors that contribute to immune suppression in the ovarian tumor microenvironment (TME). Dual blockade of PD-1 along with LAG-3 or CTLA-4 has been shown to synergistically enhance T-cell effector f...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Huang, Ruea-Yea, Francois, Ariel, McGray, AJ Robert, Miliotto, Anthony, Odunsi, Kunle
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283642/
https://ncbi.nlm.nih.gov/pubmed/28197366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1249561
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