Tumor-infiltrating NY-ESO-1–specific CD8(+) T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

NY-ESO-1 is a “cancer-testis” antigen frequently expressed in epithelial ovarian cancer (EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to understand in vivo tolerance mechanisms, we assessed the phenotype and function of NY-ESO-1–specific CD8(+) T cells derived...

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Bibliografske podrobnosti
Main Authors: Matsuzaki, Junko, Gnjatic, Sacha, Mhawech-Fauceglia, Paulette, Beck, Amy, Miller, Austin, Tsuji, Takemasa, Eppolito, Cheryl, Qian, Feng, Lele, Shashikant, Shrikant, Protul, Old, Lloyd J., Odunsi, Kunle
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867907/
https://ncbi.nlm.nih.gov/pubmed/20385810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003345107
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