Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer

The cancer-testis/cancer-germline antigen NY-ESO-1 is a vaccine target in epithelial ovarian cancer (EOC), but its limited expression is a barrier to vaccine efficacy. As NY-ESO-1 is regulated by DNA methylation, we hypothesized that DNA methyltransferase (DNMT) inhibitors may augment NY-ESO-1 vacci...

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Autori principali: Odunsi, Kunle, Matsuzaki, Junko, James, Smitha R., Mhawech-Fauceglia, Paulette, Tsuji, Takemasa, Miller, Austin, Zhang, Wa, Akers, Stacey N., Griffiths, Elizabeth A., Miliotto, Anthony, Beck, Amy, Batt, Carl A, Ritter, Gerd, Lele, Shashikant, Gnjatic, Sacha, Karpf, Adam R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925074/
https://ncbi.nlm.nih.gov/pubmed/24535937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-13-0126
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