Tumor-infiltrating NY-ESO-1–specific CD8(+) T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

NY-ESO-1 is a “cancer-testis” antigen frequently expressed in epithelial ovarian cancer (EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to understand in vivo tolerance mechanisms, we assessed the phenotype and function of NY-ESO-1–specific CD8(+) T cells derived...

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Detalles Bibliográficos
Main Authors: Matsuzaki, Junko, Gnjatic, Sacha, Mhawech-Fauceglia, Paulette, Beck, Amy, Miller, Austin, Tsuji, Takemasa, Eppolito, Cheryl, Qian, Feng, Lele, Shashikant, Shrikant, Protul, Old, Lloyd J., Odunsi, Kunle
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867907/
https://ncbi.nlm.nih.gov/pubmed/20385810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003345107
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