Tumor-infiltrating NY-ESO-1–specific CD8(+) T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

NY-ESO-1 is a “cancer-testis” antigen frequently expressed in epithelial ovarian cancer (EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to understand in vivo tolerance mechanisms, we assessed the phenotype and function of NY-ESO-1–specific CD8(+) T cells derived...

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Bibliografiske detaljer
Main Authors: Matsuzaki, Junko, Gnjatic, Sacha, Mhawech-Fauceglia, Paulette, Beck, Amy, Miller, Austin, Tsuji, Takemasa, Eppolito, Cheryl, Qian, Feng, Lele, Shashikant, Shrikant, Protul, Old, Lloyd J., Odunsi, Kunle
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867907/
https://ncbi.nlm.nih.gov/pubmed/20385810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003345107
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