Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation

In the present study, we found that selective inhibition of histone deacetylase 2 (HDAC2) with small inhibitory RNA (siRNA) induced survivin downregulation in a p53-dependent manner. Interestingly, suberoylanilide hydroxamic acid (SAHA) or knockdown of HDAC2 induced downregulation of Mdm2, a negativ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Seo, Sung-Keum, Hwang, Chang-Sun, Choe, Tae-Boo, Hong, Seok-Il, Yi, Jae Youn, Hwang, Sang-Gu, Lee, Hyun-Gyu, Oh, Sang Taek, Lee, Yun-Han, Park, In-Chul
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694920/
https://ncbi.nlm.nih.gov/pubmed/25605253
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