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Synthesis of Sulfonamides and Evaluation of Their Histone Deacetylase (HDAC) Activity
A simple synthesis of sulfonamides 4–22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N–sulfonylation of L–proline benzyl ester hydrochloride (2) and coupling reaction of N–sulfonyl chloride 3 with amines in high yields. It was found that several c...
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| Publicado no: | Molecules |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6149482/ https://ncbi.nlm.nih.gov/pubmed/17873846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/12051125 |
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