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Synthesis of Sulfonamides and Evaluation of Their Histone Deacetylase (HDAC) Activity
A simple synthesis of sulfonamides 4–22 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involve N–sulfonylation of L–proline benzyl ester hydrochloride (2) and coupling reaction of N–sulfonyl chloride 3 with amines in high yields. It was found that several c...
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| Publicado en: | Molecules |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6149482/ https://ncbi.nlm.nih.gov/pubmed/17873846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/12051125 |
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