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The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165640/ https://ncbi.nlm.nih.gov/pubmed/12840003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg315 |
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