The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Krämer, Oliver H., Zhu, Ping, Ostendorff, Heather P., Golebiewski, Martin, Tiefenbach, Jens, Peters, Marvin A., Brill, Boris, Groner, Bernd, Bach, Ingolf, Heinzel, Thorsten, Göttlicher, Martin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2003
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC165640/
https://ncbi.nlm.nih.gov/pubmed/12840003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg315
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