The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient...

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Main Authors: Krämer, Oliver H., Zhu, Ping, Ostendorff, Heather P., Golebiewski, Martin, Tiefenbach, Jens, Peters, Marvin A., Brill, Boris, Groner, Bernd, Bach, Ingolf, Heinzel, Thorsten, Göttlicher, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC165640/
https://ncbi.nlm.nih.gov/pubmed/12840003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg315
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