Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

High-level fetal (γ) globin expression ameliorates clinical severity of the beta (β) hemoglobinopathies, and safe, orally-bioavailable γ-globin inducing agents would benefit many patients. We adapted a LCR-γ-globin promoter-GFP reporter assay to a high-throughput robotic system to evaluate five dive...

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Vydáno v:PLoS One
Hlavní autoři: Boosalis, Michael S., Sangerman, Jose I., White, Gary L., Wolf, Roman F., Shen, Ling, Dai, Yan, White, Emily, Makala, Levi H., Li, Biaoru, Pace, Betty S., Nouraie, Mehdi, Faller, Douglas V., Perrine, Susan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694699/
https://ncbi.nlm.nih.gov/pubmed/26713848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144660
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