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Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo
Orally bioactive compounds that induce γ globin gene expression at tolerable doses are needed for optimal treatment of the β-hemoglobinopathies. Short-chain fatty acids (SCFAs) of 2 to 6 carbons in length induce γ globin expression in animal models, and butyrate, phenylbutyrate, and valproate induce...
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| Publicado no: | Blood |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4269367/ https://ncbi.nlm.nih.gov/pubmed/12393583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2002-02-0353 |
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