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Enhancement of growth and survival and alterations in Bcl-family proteins in β-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives

Accelerated apoptosis of erythroid progenitors is a characteristic of β-thalassemia which presents a significant barrier to definitive therapeutic approaches utilizing induction of endogenous fetal globin gene expression. γ-globin gene expression may not be inducible in, or may not be able to rescue...

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Detalhes bibliográficos
Publicado no:Blood Cells Mol Dis
Main Authors: Castaneda, Serguei, Boosalis, Michael S., Emery, David, Thies, Allison, Faller, Douglas V., Perrine, Susan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260805/
https://ncbi.nlm.nih.gov/pubmed/16099182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2005.06.007
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