Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice

BACKGROUND: β-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate β-globin chain production. The excessive unbound α-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. DESIGN AND...

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Autori principali: Srinoun, Kanitta, Svasti, Saovaros, Chumworathayee, Worrakavee, Vadolas, Jim, Vattanaviboon, Phantip, Fucharoen, Suthat, Winichagoon, Pranee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2009
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738712/
https://ncbi.nlm.nih.gov/pubmed/19608680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.005827
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