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Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex
High-level induction of fetal (γ) globin gene expression for therapy of β-hemoglobinopathies likely requires local chromatin modification and dissociation of repressor complexes for γ-globin promoter activation. A novel γ-globin–inducing short-chain fatty acid derivative (SCFAD), RB7, which was iden...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society of Hematology
2006
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895523/ https://ncbi.nlm.nih.gov/pubmed/16849648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-010934 |
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