Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

High-level induction of fetal (γ) globin gene expression for therapy of β-hemoglobinopathies likely requires local chromatin modification and dissociation of repressor complexes for γ-globin promoter activation. A novel γ-globin–inducing short-chain fatty acid derivative (SCFAD), RB7, which was iden...

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Xehetasun bibliografikoak
Egile Nagusiak: Mankidy, Rishikesh, Faller, Douglas V., Mabaera, Rodwell, Lowrey, Christopher H., Boosalis, Michael S., White, Gary L., Castaneda, Serguei A., Perrine, Susan P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society of Hematology 2006
Gaiak:
Red Cells
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895523/
https://ncbi.nlm.nih.gov/pubmed/16849648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-010934
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