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Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo

Orally bioactive compounds that induce γ globin gene expression at tolerable doses are needed for optimal treatment of the β-hemoglobinopathies. Short-chain fatty acids (SCFAs) of 2 to 6 carbons in length induce γ globin expression in animal models, and butyrate, phenylbutyrate, and valproate induce...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Pace, Betty S., White, Gary L., Dover, George J., Boosalis, Michael S., Faller, Douglas V., Perrine, Susan P.
Format: Artigo
Sprog:Inglês
Udgivet: 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269367/
https://ncbi.nlm.nih.gov/pubmed/12393583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2002-02-0353
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