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MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

The treatment of melanoma has improved markedly over the last several years with the advent of more targeted therapies. Unfortunately, complex compensation mechanisms, such as those of the mitogen-activated protein kinase (MAPK) pathway, have limited the clinical benefit of these treatments. Recentl...

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Podrobná bibliografie
Vydáno v:Drug Des Devel Ther
Hlavní autoři: Tran, Khiem A, Cheng, Michelle Y, Mitra, Anupam, Ogawa, Hiromi, Shi, Vivian Y, Olney, Laura P, Kloxin, April M, Maverakis, Emanual
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694671/
https://ncbi.nlm.nih.gov/pubmed/26730180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S93545
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