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MEK inhibition and immune responses in advanced melanoma
phase II and III clinical trials demonstrated modest anti- tumor activity of Binimetinib (MEK162) - a potent allosteric inhibitor of MEK1 and MEK2- in patients with advanced NRAS mutant melanoma. The analysis of the NEMO study in NRAS mutated melanoma, has shown that pre-treatment with immunotherapy...
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| Publicado en: | Oncoimmunology |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5593717/ https://ncbi.nlm.nih.gov/pubmed/28919996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1335843 |
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