Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as critical events in the pathophysiology of APAP-induced...

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Veröffentlicht in:J Clin Transl Res
Hauptverfasser: Xie, Yuchao, Woolbright, Benjamin L., Kos, Milan, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694640/
https://ncbi.nlm.nih.gov/pubmed/26722668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18053/jctres.201502.004
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