Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation

Infection with enterohemorrhagic Escherichia coli (EHEC) can result in severe disease, including hemorrhagic colitis and the hemolytic uremic syndrome. Shiga toxins (Stx) are the key EHEC virulence determinant contributing to severe disease. Despite inhibiting protein synthesis, Shiga toxins paradox...

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Bibliografische gegevens
Gepubliceerd in:Infect Immun
Hoofdauteurs: Jandhyala, Dakshina M., Ahluwalia, Amrita, Schimmel, Jennifer J., Rogers, Arlin B., Leong, John M., Thorpe, Cheleste M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Host Response and Inflammation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694011/
https://ncbi.nlm.nih.gov/pubmed/26483408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00977-15
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