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R4496C RyR2 mutation impairs atrial and ventricular contractility
Ryanodine receptor (RyR2) is the major Ca(2+) channel of the cardiac sarcoplasmic reticulum (SR) and plays a crucial role in the generation of myocardial force. Changes in RyR2 gating properties and resulting increases in its open probability (P(o)) are associated with Ca(2+) leakage from the SR and...
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| Publicado no: | J Gen Physiol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4692489/ https://ncbi.nlm.nih.gov/pubmed/26666913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511450 |
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