R4496C RyR2 mutation impairs atrial and ventricular contractility

Ryanodine receptor (RyR2) is the major Ca(2+) channel of the cardiac sarcoplasmic reticulum (SR) and plays a crucial role in the generation of myocardial force. Changes in RyR2 gating properties and resulting increases in its open probability (P(o)) are associated with Ca(2+) leakage from the SR and...

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Bibliografische gegevens
Gepubliceerd in:J Gen Physiol
Hoofdauteurs: Ferrantini, Cecilia, Coppini, Raffaele, Scellini, Beatrice, Ferrara, Claudia, Pioner, Josè Manuel, Mazzoni, Luca, Priori, Silvia, Cerbai, Elisabetta, Tesi, Chiara, Poggesi, Corrado
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692489/
https://ncbi.nlm.nih.gov/pubmed/26666913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511450
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