Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models

BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation‐driven changes in myofilament function combined with excitation‐contraction (E‐C) coupling abnormalities related to adverse remodeling. Whether myofilamen...

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Bibliografiske detaljer
Udgivet i:J Am Heart Assoc
Main Authors: Ferrantini, Cecilia, Coppini, Raffaele, Pioner, Josè Manuel, Gentile, Francesca, Tosi, Benedetta, Mazzoni, Luca, Scellini, Beatrice, Piroddi, Nicoletta, Laurino, Annunziatina, Santini, Lorenzo, Spinelli, Valentina, Sacconi, Leonardo, De Tombe, Pieter, Moore, Rachel, Tardiff, Jil, Mugelli, Alessandro, Olivotto, Iacopo, Cerbai, Elisabetta, Tesi, Chiara, Poggesi, Corrado
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586279/
https://ncbi.nlm.nih.gov/pubmed/28735292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.005407
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