Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models

BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation‐driven changes in myofilament function combined with excitation‐contraction (E‐C) coupling abnormalities related to adverse remodeling. Whether myofilamen...

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Bibliografiset tiedot
Julkaisussa:J Am Heart Assoc
Päätekijät: Ferrantini, Cecilia, Coppini, Raffaele, Pioner, Josè Manuel, Gentile, Francesca, Tosi, Benedetta, Mazzoni, Luca, Scellini, Beatrice, Piroddi, Nicoletta, Laurino, Annunziatina, Santini, Lorenzo, Spinelli, Valentina, Sacconi, Leonardo, De Tombe, Pieter, Moore, Rachel, Tardiff, Jil, Mugelli, Alessandro, Olivotto, Iacopo, Cerbai, Elisabetta, Tesi, Chiara, Poggesi, Corrado
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586279/
https://ncbi.nlm.nih.gov/pubmed/28735292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.005407
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