Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models

BACKGROUND: In cardiomyocytes from patients with hypertrophic cardiomyopathy, mechanical dysfunction and arrhythmogenicity are caused by mutation‐driven changes in myofilament function combined with excitation‐contraction (E‐C) coupling abnormalities related to adverse remodeling. Whether myofilamen...

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Bibliografische gegevens
Gepubliceerd in:J Am Heart Assoc
Hoofdauteurs: Ferrantini, Cecilia, Coppini, Raffaele, Pioner, Josè Manuel, Gentile, Francesca, Tosi, Benedetta, Mazzoni, Luca, Scellini, Beatrice, Piroddi, Nicoletta, Laurino, Annunziatina, Santini, Lorenzo, Spinelli, Valentina, Sacconi, Leonardo, De Tombe, Pieter, Moore, Rachel, Tardiff, Jil, Mugelli, Alessandro, Olivotto, Iacopo, Cerbai, Elisabetta, Tesi, Chiara, Poggesi, Corrado
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586279/
https://ncbi.nlm.nih.gov/pubmed/28735292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.005407
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