Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium

BACKGROUND AND PURPOSE: In 30–40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine‐induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β‐bl...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Br J Pharmacol
Päätekijät: Ferrantini, Cecilia, Pioner, Josè Manuel, Mazzoni, Luca, Gentile, Francesca, Tosi, Benedetta, Rossi, Alessandra, Belardinelli, Luiz, Tesi, Chiara, Palandri, Chiara, Matucci, Rosanna, Cerbai, Elisabetta, Olivotto, Iacopo, Poggesi, Corrado, Mugelli, Alessandro, Coppini, Raffaele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2018
Aiheet:
Research Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003658/
https://ncbi.nlm.nih.gov/pubmed/29579779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14223
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