Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium

BACKGROUND AND PURPOSE: In 30–40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine‐induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β‐bl...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ferrantini, Cecilia, Pioner, Josè Manuel, Mazzoni, Luca, Gentile, Francesca, Tosi, Benedetta, Rossi, Alessandra, Belardinelli, Luiz, Tesi, Chiara, Palandri, Chiara, Matucci, Rosanna, Cerbai, Elisabetta, Olivotto, Iacopo, Poggesi, Corrado, Mugelli, Alessandro, Coppini, Raffaele
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003658/
https://ncbi.nlm.nih.gov/pubmed/29579779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14223
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