Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium

BACKGROUND AND PURPOSE: In 30–40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine‐induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β‐bl...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Ferrantini, Cecilia, Pioner, Josè Manuel, Mazzoni, Luca, Gentile, Francesca, Tosi, Benedetta, Rossi, Alessandra, Belardinelli, Luiz, Tesi, Chiara, Palandri, Chiara, Matucci, Rosanna, Cerbai, Elisabetta, Olivotto, Iacopo, Poggesi, Corrado, Mugelli, Alessandro, Coppini, Raffaele
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003658/
https://ncbi.nlm.nih.gov/pubmed/29579779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14223
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires