SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational...

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Vydáno v:Genome Res
Hlavní autoři: Shen, Yue, Stracquadanio, Giovanni, Wang, Yun, Yang, Kun, Mitchell, Leslie A., Xue, Yaxin, Cai, Yizhi, Chen, Tai, Dymond, Jessica S., Kang, Kang, Gong, Jianhui, Zeng, Xiaofan, Zhang, Yongfen, Li, Yingrui, Feng, Qiang, Xu, Xun, Wang, Jun, Wang, Jian, Yang, Huanming, Boeke, Jef D., Bader, Joel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691749/
https://ncbi.nlm.nih.gov/pubmed/26566658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.193433.115
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