SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational...

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Publicado en:Genome Res
Autores principales: Shen, Yue, Stracquadanio, Giovanni, Wang, Yun, Yang, Kun, Mitchell, Leslie A., Xue, Yaxin, Cai, Yizhi, Chen, Tai, Dymond, Jessica S., Kang, Kang, Gong, Jianhui, Zeng, Xiaofan, Zhang, Yongfen, Li, Yingrui, Feng, Qiang, Xu, Xun, Wang, Jun, Wang, Jian, Yang, Huanming, Boeke, Jef D., Bader, Joel S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691749/
https://ncbi.nlm.nih.gov/pubmed/26566658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.193433.115
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