SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43 recombinase sites) and then used a computational...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Shen, Yue, Stracquadanio, Giovanni, Wang, Yun, Yang, Kun, Mitchell, Leslie A., Xue, Yaxin, Cai, Yizhi, Chen, Tai, Dymond, Jessica S., Kang, Kang, Gong, Jianhui, Zeng, Xiaofan, Zhang, Yongfen, Li, Yingrui, Feng, Qiang, Xu, Xun, Wang, Jun, Wang, Jian, Yang, Huanming, Boeke, Jef D., Bader, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691749/
https://ncbi.nlm.nih.gov/pubmed/26566658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.193433.115
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