RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability

JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPN). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPN is nevertheless characterized by genomic stability. In this study, we address this paradox by identifying the DNA helicase RECQL5...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Chen, Edwin, Ahn, Jong Sook, Sykes, David B., Breyfogle, Lawrence J., Godfrey, Anna L., Nangalia, Jyoti, Ko, Amy, DeAngelo, Daniel J., Green, Anthony R., Mullally, Ann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691544/
https://ncbi.nlm.nih.gov/pubmed/26686625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.037
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