RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability

JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPN). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPN is nevertheless characterized by genomic stability. In this study, we address this paradox by identifying the DNA helicase RECQL5...

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Библиографические подробности
Опубликовано в: :Cell Rep
Главные авторы: Chen, Edwin, Ahn, Jong Sook, Sykes, David B., Breyfogle, Lawrence J., Godfrey, Anna L., Nangalia, Jyoti, Ko, Amy, DeAngelo, Daniel J., Green, Anthony R., Mullally, Ann
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691544/
https://ncbi.nlm.nih.gov/pubmed/26686625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.037
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