RECQL5 suppresses oncogenic JAK2-induced replication stress and genomic instability

JAK2V617F is the most common oncogenic lesion in patients with myeloproliferative neoplasms (MPN). Despite the ability of JAK2V617F to instigate DNA damage in vitro, MPN is nevertheless characterized by genomic stability. In this study, we address this paradox by identifying the DNA helicase RECQL5...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Chen, Edwin, Ahn, Jong Sook, Sykes, David B., Breyfogle, Lawrence J., Godfrey, Anna L., Nangalia, Jyoti, Ko, Amy, DeAngelo, Daniel J., Green, Anthony R., Mullally, Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691544/
https://ncbi.nlm.nih.gov/pubmed/26686625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.037
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados